In this episode of "In the Interim…" guest host Cooper Berry moderates a detailed discussion on the evolution and practice of Bayesian methodology in clinical trials with fellow family members Dr. Don Berry, Dr. Scott Berry, Dr. Lindsay Berry, and Dr. Nick Berry. The panel outlines the foundational principles of Bayesian decision-making in medical research, ethical debates informed by historical reports like the Belmont Report, and the shift in regulatory acceptance. Computational developments such as Markov Chain Monte Carlo (MCMC) are examined for their role in enabling applied Bayesian models. Panelists give practical accounts of implementing adaptive and platform trials, including I-SPY 2 and REMAP-CAP, and analyze challenges faced during the COVID-19 pandemic. The implications of Bayesian statistics in artificial intelligence and contemporary clinical decision-making are explored, highlighting ongoing shifts in trial design and evidence synthesis. Each discussion is grounded in direct experience and technical rigor, providing insight into both the operational realities and future trajectory of Bayesian-driven methods in clinical research.Key Highlights:Historical development of Bayesian clinical trial design and foundational influence from Leonard J. Savage to current methodsEthical tension in trial conduct, referencing the Belmont Report and equipoiseAdvances in computation and Markov Chain Monte Carlo (MCMC)Regulatory frameworks for Bayesian adaptive trials, including FDA guidanceImplementation details from I-SPY 2 and REMAP-CAP platform trialsBayesian methodology in the context of artificial intelligence, precision medicine, and future data integrationFor more, visit us at https://www.berryconsultants.com/

In this episode of the Breakthrough Church Podcast, Josh Brake shares candid reflections on following the leading of the Holy Spirit in both personal discipleship and church leadership. Josh recounts real-life moments of stepping out in faith, sharing the gospel on a college campus, and discovering how reliance on the Spirit transforms both message and mission. Listeners will hear honest stories of challenge and encouragement, as well as practical insights into living a Jesus-centered life that welcomes the unexpected. Tune in for a heartfelt exploration of what it means to follow Jesus beyond familiar routines and into meaningful encounters.Chapters(00:00) Wrestling with Sermon Preparation and Discipleship(02:28) Encountering Jesus in Prayer and Scripture(06:55) Urgency to Follow Jesus and Evangelize(09:19) Sharing the Gospel Boldly at UTD(14:03) Meaningful Encounters and Spirit-Led Prayer(16:26) True Neediness Before Jesus(18:38) The Holy Spirit’s Role in Leading the Church

In this episode of AWM Insights, Chief Investment Officer Justin Dyer and Portfolio Manager Mena Hanna break down the latest volatility in global markets and discuss what it really means for investor portfolios. Together, they explore the key forces driving market swings—from sticky inflation and central bank policies to shifting sentiment around tech stocks and cryptocurrencies. With candid insights and practical analogies, Justin and Mena reveal why volatility is not the enemy but a necessary part of building long-term wealth. Whether you’re worried by red numbers or tempted to chase market trends, this conversation offers a steady-handed playbook for making sound investment decisions under uncertainty.Connect with UsCall or text us: 626-862-0355Website: https://www.athletefamilyoffice.com/YouTube: https://www.youtube.com/channel/UCc1NxpK21N1vKWEExC45YEALinkedIn: https://www.linkedin.com/company/awmcapital/Instagram: https://www.instagram.com/awmcapital/X: https://twitter.com/awmcapitalFacebook: https://www.facebook.com/awmcapital/Chapters(00:00) Market Volatility and Recent Performance(02:00) Forces Driving the Current Market(05:00) Shifting from Optimism to Realism(06:00) The Role of Risk and Volatility in Investing(08:00) Singles and Doubles Versus Chasing Home Runs(09:30) Making Good Decisions Amid Uncertainty(10:45) Sticking to Your Investing Playbook

In this episode, Adam Hatcher reflects on his own journey of joining the family business and the realities that come with stepping into a company run by relatives. Featuring a conversation with Andrea Carpenter, president of Transition Strategists and host of Your Next Gen Friend podcast, the discussion unpacks firsthand stories about generational expectations, mixing family ties with company roles, and the challenges of growing into leadership. Listeners will gain honest perspectives on navigating tension, building independence, and chaos-proofing the family business from someone who has lived it. If you’re considering bringing family into your organization—or are part of one already—this episode brings practical insight for every stage of the journey.Links for Andrea CarpenterWebsite: https://transitionstrategists.com/Your Next Gen Friend Podcast: https://podcasts.apple.com/us/podcast/your-next-gen-friend-a-successors-guide-to-business/id1821493103LinkedIn: https://www.linkedin.com/in/andreashaverInstagram: https://www.instagram.com/yournextgenfriend/21C LinksTwenty One Clear website: www.21clear.comAdam Hatcher on LinkedIn - www.linkedin.com/in/adamhatcherSubscribe to the Twenty One Clear newsletter: https://21clear.substack.com/Subscribe to the podcast and listen to the previous three episodes that this episode builds upon: https://podcasts.apple.com/us/podcast/the-twenty-one-clear-podcast/id1811403547Bumper MusicStill Hotby Nic D, Connor Price(c) Lossless, 2023Episode Produced Byhttps://snapmarket.coChapters(00:00) Reflecting on Joining the Family Business(02:56) Advice from Other Family Business Leaders(06:30) Value of Independent Experience(11:05) Generational Stories and Building on the Past(15:15) Navigating Authority and Tension in Leadership(20:00) Mixing Family and Business Dynamics(27:00) Honest Conversations and Growth Decisions

Continuing our Ownership Series, in this episode Paul Spencer unpacks the real value behind recurring revenue for business owners, exploring what makes it the true engine of long-term business health. Drawing from decades of hands-on experience across industries, Paul discusses the practical challenges of cash flow, the nuts and bolts of recurring revenue models, and ways to create lasting value through products and services that customers need again and again. Along the way, he shares memorable stories, hard-won lessons, and practical strategies every owner can use to strengthen their business for the future. If you’re ready to rethink how your company generates value and builds resilience, this episode delivers straightforward advice and new perspectives you can put into practice today.Connect with PaulWebsite: https://www.secondnature.solutions/Subscribe to the newsletter: https://www.secondnature.solutions/joinLinkedIn: https://www.linkedin.com/in/paul-spencer-7252118/Chapters(00:01) The Commitment and Purpose of Ownership(02:23) Eight Key Value Drivers in Business(04:49) The Impact of Accounts Receivable on Value(07:16) Defining and Creating Recurring Revenue(12:04) Forms and Models of Recurring Revenue(16:53) Strategies for Recurring Revenue Across Industries(19:16) Stickiness, Ecosystem, and Limitations of One-Time Sales