In episode 40 of "In the Interim…", Dr. Scott Berry examines the statistical, operational, and behavioral challenges of using interim analyses as triggers for funding in adaptive and seamless Phase II/III clinical trials. The episode presents a typical hypothetical scenario for rare disease drug development, contrasting conventional two-stage development with a seamless design and highlighting efficiency gains in sample size, patient allocation, and trial duration. Scott details the construction of administrative (financial) interim analyses, underscoring their distinction from futility analyses and their role in funding decisions when complete funding is not secured upfront. He addresses FDA operational bias concerns, emphasizing blinding and limiting information sharing to protect trial integrity. Finally, the episode focuses on developing objective interim funding criteria—using Bayesian predictive probability and assurance—and on leveraging illustrative simulation outputs and sample datasets to bridge the “I’ll know it when I see it” divide between scientists and funders. Practical, empirical, and tailored to real funding barriers in clinical research.Key HighlightsStatistical structure and efficiency of seamless Phase II/III trial designsAdministrative (financial) interim analysis setup as funding decision triggers, distinct from futility analysesFDA operational bias guidance and requirements for trial blindingPredictive probability and assurance as objective interim criteriaSample data and simulation outputs to facilitate stakeholder alignmentFor more, visit us at https://www.berryconsultants.com/

In this episode of AWM Insights, Chief Investment Officer Justin Dyer and Portfolio Manager Mena Hanna break down the dynamic world of private market investing. Together, they explore the explosive growth of private markets, the distinct strategies that separate institutional investors from individual ones, and the myths and realities of access to exclusive opportunities. Discover why diversification, data analysis, and a disciplined approach matter more than chasing the next hot startup. Whether you’re curious about the potential of private markets or looking to refine your investment playbook, this discussion offers practical wisdom and sharp insights you won’t want to miss.Connect with UsCall or text us: 626-862-0355Website: https://www.athletefamilyoffice.com/YouTube: https://www.youtube.com/channel/UCc1NxpK21N1vKWEExC45YEALinkedIn: https://www.linkedin.com/company/awmcapital/Instagram: https://www.instagram.com/awmcapital/X: https://twitter.com/awmcapitalFacebook: https://www.facebook.com/awmcapital/Chapters(00:00) Introduction to Private Market Investing(01:00) Growth and Complexity of Private Markets(03:00) Institutional Approach Versus Individual Investing(05:00) Access and its True Value(08:00) Importance of Data and Base Rate Probabilities(09:00) Pitfalls of One-Off and Product-Driven Investing(11:00) Diversification and Building a Playbook

We're back with the next installment in our Ownership series, this time looking at the vital concept of "Right to Win". In this episode, Paul Spencer unpacks the realities of business ownership, sharing why it isn't the right path for everyone and what truly sets successful owners apart — whether they are entrepreneurs or intrapreneurs. He then turns to Right to Win, explaining the importance of standing out in your industry, and the power of building a strong reputation and memorable brand. Listeners will gain practical strategies for creating lasting value through differentiation, process excellence, and a long-term vision. Connect with PaulWebsite: https://www.secondnature.solutions/Subscribe to the newsletter: https://www.secondnature.solutions/joinLinkedIn: https://www.linkedin.com/in/paul-spencer-7252118/Chapters(00:01) The Realities of Business Ownership(02:17) Entrepreneur vs Intrapreneur Roles(04:20) Overview of Ownership Evaluation Criteria(05:30) Understanding Right to Win(06:50) Blue Ocean Strategy and Differentiation(12:00) Value of Process, Culture, and Brand(14:40) Ecosystems, Stickiness, and Market Position(16:23) Margins, Multiples, and Long-Term Impact of Right to Win

In this episode of the Travel Buddy podcast, Ian Andersen and Rachel Satow take a close look at how to align rewards and recognition programs with team goals and KPIs for a more motivated, high-performing workforce. Together, they unpack common pitfalls of traditional rewards, share practical strategies for building meaningful incentives, and explore the surprising role travel can play in driving engagement and innovation. Tune in for expert insights, memorable anecdotes, and actionable tips to help you design rewards that truly move the needle for your team in 2026 and beyond.Chapters(00:01) Challenges With Traditional Rewards Programs(04:22) Aligning Incentives With Team Goals and KPIs(12:20) Building Culture and Recognition Through Alignment(17:20) Individual Versus Team-Based Recognition(23:05) Integrating Travel Into Rewards Programs(28:55) Practical Strategies for KPI-Aligned RewardsContinue Your Journeyhttps://www.switchfly.com/blog/adventure-at-work-travel-rewards-innovationConnect with SwitchflyWebsite: https://www.switchfly.com/LinkedIn: https://www.linkedin.com/company/switchfly/X: https://twitter.com/switchflyYouTube: https://www.youtube.com/@SwitchflyOfficial

Join hosts Riccardo Stewart, Sam Acho, Zach Miller, and Jeff Locke—NFL veterans with a combined 20 years of experience on and off the field—as they break down the "Four Ts" of investing for professional athletes: truth, touch, time, and tension. Drawing from their personal journeys and financial expertise, the team explores how to identify trustworthy advisors, navigate the relational side of wealth, practice patience amidst high-earning years, and tackle inevitable challenges along the way. If you want to make smarter decisions, build generational wealth, and avoid the common pitfalls NFL players face, this episode delivers candid advice and real-life stories you won’t want to miss.Connect with usCall or text: 602-989-5022Website: https://www.athletefamilyoffice.com/LinkedIn: https://www.linkedin.com/company/awmcapital/Instagram: https://www.instagram.com/awmcapital/Facebook: https://www.facebook.com/awmcapital/X: https://twitter.com/awmcapitalChapters(00:01) The Four Ts of Investing(01:18) The Truth About Advisors and Incentives(03:25) The Importance of Relationship and Trust(06:45) Patience and the Role of Time(09:21) Navigating Tension and Uncertainty