In this episode of the Sam Acho podcast, Sam and Clif Marshall welcome Matt Wright, a former pastor and current executive coach, to discuss his journey in ministry, the importance of community, and the challenges of grief during the holiday season. They explore the concept of pastoring beyond traditional roles, emphasizing that everyone can be a pastor in their own right. Matt shares insights on parenting, the significance of identity and affirmation, and how to navigate the complexities of building authentic relationships in a digital age. The conversation highlights the importance of abiding in faith and the impact of leadership in various spheres of life.

In this episode of "In the Interim…", host Dr. Scott Berry and frequent co-host Dr. Kert Viele, Senior Statistical Scientist at Berry Consultants, analyze the potential shift in FDA regulatory policy from requiring two independent trials to accepting a single trial as sufficient for “substantial evidence” in drug approvals. Reflecting on the statutory and regulatory definitions originating with the 1962 Federal Food, Drug, and Cosmetic Act and 21 CFR 314.126, they dissect current and emerging interpretations, referencing recent statements by Dr. Martin Makary and coverage described in a STAT article. The conversation focuses on the scientific and statistical foundations of the two-trial threshold, challenges with dichotomous results, and how pooled evidence might increase efficiency and rigor. They discuss statistical implications including alpha thresholds, sample size effects, program power, and the consequences for clinical labeling. The episode also introduces Bayesian approaches as a method for integrating totality of evidence. Attention is given to both population breadth and the possible risks of a narrowed evidentiary base under a single-trial standard.Key HighlightsRegulatory and historical context of “substantial evidence” since 1962 and current FDA directives.Industry practice: simultaneous Phase III trials, statistical power, and evidentiary replication.Criticism of binary, trial-level significance thresholds; merits of pooling or meta-analysis.Potential efficiency gains and tradeoffs with a more stringent alpha requirement for single trials.Strategic and operational effects on trial design, sample size, and label indications.Bayesian statistical approaches for full evidence integration, discussed as an analytical viewpoint.

In this episode of the Breakthrough Church podcast, Josh Brake reflects on the complexities of Christmas, emphasizing that it is a time of both joy and sorrow. He discusses the significance of Christmas as a beginning rather than an end, highlighting the story of Jesus and the hope it brings. The conversation shifts to the importance of seeking Jesus amidst family gatherings and holiday festivities. As the New Year approaches, Josh encourages listeners to consider their resolutions in light of being about the Father's business and emphasizes the transformative power of prayer in deepening one's relationship with God.Chapters00:00 The Aftermath of Christmas: Reflections and Realities02:48 The Story of Hope: Christmas as a Beginning06:02 Searching for Jesus: Amidst Family and Festivities08:52 Being About the Father's Business: New Year Resolutions12:10 The Power of Prayer: Transforming Lives and Ministries

In this inspiring episode of the Sam Acho Podcast, Sam Acho sits down with Mo Isom Aiken, a dynamic speaker, author, and spiritual mentor. Together, they explore the profound journey of faith, obedience, and transformation. Mo shares her personal experiences of radical surrender, from her college days to her life-changing decision to embark on a two-year intimacy fast. Discover how Mo's unwavering faith led her to sell everything, travel across the U.S. with her family, and ultimately find her calling in ministry. This episode is a testament to the power of saying "yes" to God and living a life of purpose and adventure. Tune in for a conversation that will challenge and inspire you to embrace your own journey of faith at  samacho.com

In this episode of "In the Interim…", Dr. Jenny Devenport, Global Head of Methods, Collaboration, and Outreach at Roche, joins Dr. Scott Berry for a detailed discussion on career evolution, statistical culture, and communication in the pharmaceutical industry. Dr. Devenport describes her transition from psychology in New Mexico to statistical leadership in Basel, emphasizing the formative role of early academic mentors and her experience working across the US and Europe. She outlines her current functions in methods development, internal collaboration, and industry outreach, highlighting active engagement with academic and regulatory communities. The episode scrutinizes differences in workplace culture, such as the emphasis on debate and long-term collaboration in Europe, and differences in educational backgrounds among statisticians. The conversation covers practical barriers and slow adoption of Bayesian methods and the importance of communication in the acceptance of futility analyses in pharma, the importance of scale in problem-solving, and the emergence of AI as a tool for statisticians. Dr. Devenport provides pragmatic strategies for statisticians to improve their influence through tailored, audience-specific communication.Key HighlightsDr. Devenport’s academic and geographic move from the US to EuropeResponsibilities in methods development, collaboration, and outreach at RocheContrasts in US and European pharmaceutical statistics culturesMeasured perspective on AI’s effect on statisticians’ responsibilitiesPractical guidance for statisticians on communication and influence