In episode 37 of "In the Interim…", Dr. Jeff Saver, Director of the UCLA Comprehensive Stroke and Vascular Neurology Program, details his shift from behavioral neurology to clinical stroke research after early engagement with multicenter trials like TOAST. The discussion covers the biology of acute ischemic stroke, quantifying neuronal loss, and the scientific underpinnings of “time is brain.” Dr. Saver outlines the evolution of endovascular therapy, from early device challenges to current reperfusion success rates exceeding 85%. Key methodological issues in stroke trial analyses are presented, including debate over endpoint selection—dichotomous versus ordinal approaches and the limitations therein. Special focus is placed on the utility-weighted modified Rankin Scale, which assigns empirically derived, patient-centered health values to each disability state, providing a comprehensive measure that captures both benefit and harm. The episode explores regulatory hesitancy, differing analytic preferences within the field, and the design prospects for neuroprotectant interventions. Heterogeneity in patient outcomes and implications for public health and trial methodology are addressed. The episode provides an empirical account of clinical trial endpoint selection, interpretation, and future directions in cerebrovascular research.Key HighlightsEarly career influences and pivotal trial participation.Pathophysiology and quantification of acute stroke injury.Endovascular device development and clinical impact.Comparative analysis of endpoint methods: dichotomous, ordinal, and utility-weighted approaches.Technical derivation and application of utility-weighted mRS.Ongoing regulatory and methodological debate.Heterogeneity in ischemic vulnerability and future trial directions.For more, visit us at https://www.berryconsultants.com/

In this episode of AWM Insights, Chief Investment Officer Justin Dyer and Portfolio Manager Mena Hanna wrap up their series on winning through disciplined investing and sound decision-making. They break down why a strong defense—both in sports and in your portfolio—is the bedrock of long-term success and multi-generational wealth. Through candid insights and relatable sports analogies, Justin and Mena reveal how defensive strategies, diversification, and resilient processes give families the edge to thrive, with stories and practical play-calling advice you can apply right now. Tune in to learn how to build a championship-winning plan for your wealth and legacy.Connect with UsCall or text us: 626-862-0355Website: https://www.athletefamilyoffice.com/YouTube: https://www.youtube.com/channel/UCc1NxpK21N1vKWEExC45YEALinkedIn: https://www.linkedin.com/company/awmcapital/Instagram: https://www.instagram.com/awmcapital/X: https://twitter.com/awmcapitalFacebook: https://www.facebook.com/awmcapital/Chapters(00:00) Defensive Strategy Wins Championships(02:50) Building a Playbook for Investing(04:03) Bonds and the Role of Defense(06:40) Diversification as Offensive Defense(07:38) Decision-Making and Play Calling(10:23) Discipline and Multi-Generational Confidence

In this powerful episode of The Sam Acho Podcast, Lamorris Crawford shares his remarkable journey from growing up in the rough streets of Chicago to serving as the team chaplain for the Carolina Panthers. Through his story, Lamorris reveals how faith, identity, and purpose shaped his life and marriage  and how they continue to guide him in the world of professional sports.He opens up about the challenges of high divorce rates among athletes, the dangers of finding identity in performance, and what it really means to “deflect the glory” back to God. Lamorris and Sam dive deep into conversations on parenting, overcoming adversity, and finding strength through community and faith including Lamorris’s inspiring account of walking alongside his wife through her battle with MS.Whether you’re an athlete, a parent, or simply navigating life’s challenges, this episode reminds you that true fulfillment comes not from what you do, but from who you are in Christ.Key Topics:Faith and identity beyond performanceMarriage and spiritual grounding in sportsOvercoming adversity and the power of communityParenting, purpose, and protecting what matters mostLiving a life that deflects glory back to God