In this episode of "In the Interim...", Dr. Scott Berry dissects prevailing concepts of “clinically meaningful difference” in clinical trials focusing on progressive diseases. Through detailed examples from pancreatic cancer (Ben Sasse, Revolution Medicines), emphysema (Elevair), Alzheimer’s disease (lecanemab), and IVF, Scott challenges the adequacy of the population-mean of a continuous outcome in reflecting true patient benefit. The episode discusses inconsistent usage and interpretation of acronyms such as MCID, CSD, and Target Product Profile (TPP). Dr. Berry advises trialists to resist interpreting the mean difference using patient-level minimal effects, and adopt responder analyses and cumulative probability approaches to enhance patient-level relevance. Guidance is offered for analyzing the effect of time-saved instead of a mean differences in a clinical endpoint at a single time for progressive diseases – measuring “sweet time.” Key Highlights Focus on added time not the change from baseline as the most meaningful outcome for a progressive disease. In-depth evaluation of MCID, CSD, TPP, and risk of misinterpretation. Critique of trying to interpret mean-based endpoints for clinical meaningfulness such as six-minute walk distance and CDR sum of boxes. FDA advisory panel guidance on MCID for IVF live birth endpoints and dichotomous versus continuous endpoints. Advocacy for responder analyses and cumulative probability of achieving thresholds in reporting the clinical effect of a treatment. For more, visit us at https://www.berryconsultants.com/

Everyone talks about the number on a signing bonus. Almost nobody talks about what happens to it before it reaches your account. In this episode, the guys break down when rookies and veterans actually get paid, why the state you play in and the team you sign with change how much you keep, and the specific tax-withholding strategy AWM's team used to put an extra $100,000 back in one client's pocket — all without any of it becoming a guessing game. Chapters [00:00] Welcome back to the NFL Players' Podcast [00:00] Setting up today's topic: what's really happening behind the scenes with your signing bonus [00:01] Why most rookies sign and walk away without asking the right questions [00:02] When rookies actually get paid — the 15-day portion and the delayed remainder [00:03] Veterans vs. rookies: how payment timing and negotiation differ [00:03] The jock tax explained: how state and team both affect what you keep [00:04] Newsflash: your full signing bonus doesn't hit your account [00:05] Behind AWM's numbers: $45M+ in gross client signing bonuses this off-season [00:06] Jeff's world: what AWM's tax team does the moment a client signs [00:07] Two ways teams handle withholding — and the $100K strategy that worked [00:08] Why team payroll departments say no one else does this [00:09] The long-term payoff: paying more now to pay less later, the right way Connect with us • Call or text: 602-989-5022 • Website: https://www.athletefamilyoffice.com/ • LinkedIn: https://www.linkedin.com/company/awmcapital/ • Instagram: https://www.instagram.com/awmcapital/ • Facebook: https://www.facebook.com/awmcapital/ • X: https://twitter.com/awmcapital

The script flips. After two episodes of Adam interviewing Norm Smallwood — co-founder of The RBL Group and Adam's collaborator in restructuring his own family's company — Norm turns the tables and interviews Adam. They cover why Adam started Twenty One Clear, the inner family business hiding inside every family company, why succession is nothing like a baton handoff, and the two words Adam gives every family that works together: Do Not Drift. The episode closes with an impromptu case study from Norm's own consulting work, where an HR leadership succession project took a sudden inner family business turn. 21C links Twenty One Clear website: https://www.21clear.com?utm_source=twenty-one-clear&utm_medium=website&utm_campaign=ep-14-the-company-and-your-inner-family-business&utm_content=show-notes Adam Hatcher on LinkedIn: https://www.linkedin.com/in/adamhatcher?utm_source=twenty-one-clear&utm_medium=website&utm_campaign=ep-14-the-company-and-your-inner-family-business&utm_content=show-notes Subscribe to the Twenty One Clear newsletter: https://21clear.substack.com/?utm_source=twenty-one-clear&utm_medium=email&utm_campaign=ep-14-the-company-and-your-inner-family-business&utm_content=show-notes The RBL Group (Norm Smallwood): https://www.rbl.net/?utm_source=twenty-one-clear&utm_medium=website&utm_campaign=ep-14-the-company-and-your-inner-family-business&utm_content=show-notes Episode 12, Four Stages of Leadership, Part 1: https://21clear.transistor.fm/episodes/four-stages-of-leadership-part-1-stages-1-3?utm_source=twenty-one-clear&utm_medium=website&utm_campaign=ep-14-the-company-and-your-inner-family-business&utm_content=show-notes Episode 13, Four Stages of Leadership, Part 2: https://21clear.transistor.fm/episodes/four-stages-of-leadership-part-2-stage-4-and-the-stages-importance?utm_source=twenty-one-clear&utm_medium=website&utm_campaign=ep-14-the-company-and-your-inner-family-business&utm_content=show-notes Bumper music: "Still Hot" by Nic D, Connor Price © Lossless, 2023 Episode produced by: https://snapmarket.co Chapters [00:00] Welcome and Setup — Adam flips the script: after two episodes interviewing Norm Smallwood, Norm interviews him [02:29] What Makes a Great Family Company — Full valuation for your size and industry, plus real impact, at any scale [03:47] Why "Twenty One Clear" — A 70-year-old family company, and mixing the unconditional with the conditional [07:59] The Question Behind the Firm — Why some family companies seem chaos proof and others lose value and relationships [09:30] Inside "Chaos Proof Your Business" — Who the book is for and the question it wrestles with [11:59] The Inner Family Business — One box inside another, and what the Chick-fil-A thought experiment reveals [13:51] The Hardest Management Job on Earth — Why a family exit is fundamentally different from any other departure [15:15] Norm's Case Study — A chairman's succession plan for a son who never wanted the job [17:38] Succession Is Not a Baton Handoff — Two archers, 50 yards apart, and why the arrows must meet mid-air [18:49] Do Not Drift — The one concept Adam gives every family company [19:33] The Family Is a System — How one raise reaches every family member, inside the company and out [21:41] The Headlines Exercise — Surfacing unsaid expectations before they walk into the boardroom [23:24] Twenty One Clear in Five Years — The roadmap families need and the chaos proof framework [26:31] Why a Template Is Not a Facilitator — What AI can draft and what it can never do in a family meeting [28:53] Final Advice — Do Not Drift, and open the lens as wide as you can [30:54] The Third Word — What Adam's sister and the family council gave back to the company [33:24] Closing — Continue to write your story

Roger Ferguson Jr. has held two of the most consequential seats in American finance: Vice Chairman of the Federal Reserve and, later, CEO of TIAA, where he nearly tripled assets under management while steering the company through the Global Financial Crisis, COVID, and more. In Part 1 of our three-part conversation, Roger traces the dining-room-table discipline that shaped him, his philosophy on raising kids who earn their own confidence, and the preparation habits that turned "Roger who?" into the Fed's second-most-powerful voice in under two years, all the way through to the values-driven investing chapter he's building now. Connect with Us Call or text us: 626-862-0355 Website: https://www.athletefamilyoffice.com/ YouTube: https://www.youtube.com/channel/UCc1NxpK21N1vKWEExC45YEA LinkedIn: https://www.linkedin.com/company/awmcapital/ Instagram: https://www.instagram.com/awmcapital/ X: https://twitter.com/awmcapital Facebook: https://www.facebook.com/awmcapital/ Chapters [00:00] Introduction [00:02] The Dining Room Table [00:08] Money As A Tool, Not A Scorecard [00:16] Sweeping The Shed At Harvard [00:22] Raising Kids Who Earn Their Confidence [00:29] Meeting His Wife and Co-CEO [00:34] From "Roger Who?" To Vice Chairman of the Fed [00:47] Compete, Don't Compare [00:52] Taking Over TIAA In The Eye Of The GFC [01:04] Knowing When To Leave [01:09] What's Next [01:12] Do Well And Do Good #RogerFergusonJr #FederalReserve #TIAA #1hundredyearfamily #generationalwealth #financialliteracy #crisisleadership #deferredgratification #GlobalFinancialCrisis #mentalperformance #AWMCapital #AthleteFamilyOffice

In this episode of Travel Buddy by Switchfly, Ian Andersen is joined by Lucy Mui, Switchfly’s Market Manager and self-proclaimed solo travel enthusiast. Together, they explore the rise of solo adventures, the allure of “main character” trips, and how technology is making independent travel easier and more rewarding than ever. Lucy shares her personal journeys to destinations around the world, and offers practical insights into flexibility, personalization, and the power of authentic connections on the road. Tune in for a lively discussion brimming with tips, stories, and ideas to inspire your next memorable solo getaway. Chapters (00:00) Introductions and Solo Travel Experiences (03:00) Defining Solo Travel and Personal Motivation (08:00) Technology’s Impact on Travel Confidence (09:00) Embracing Soft Adventure Travel (11:00) The Main Character Trip and Personal Fulfillment (19:00) Connection, Social Media, and Serendipity (28:00) Implications for Travel and Loyalty Program Leaders Connect with Switchfly Website: https://www.switchfly.com/ LinkedIn: https://www.linkedin.com/company/switchfly/ X: https://twitter.com/switchfly YouTube: https://www.youtube.com/@SwitchflyOfficial