Dr. Nathan O’Hara (University of Maryland), Dr. Gerard Slobogean (UC Irvine), and Dr. Sheila Sprague (McMaster University) describe the launch and design of the Musculoskeletal Adaptive Platform Trial (MAPT)—the first major adaptive platform trial in orthopaedic surgery. The discussion covers MAPT’s master protocol structure, patient-centered endpoint framework, and operational strategies for multinational implementation. Focus areas include the FASTER-HIP domain’s use of Bayesian modeling with a hierarchical clinical endpoint and the standards established for adaptation, data coordination, and future scalability. Listeners gain insight into a trial infrastructure designed to lower barriers for evidence generation and facilitate ongoing evidence generation in musculoskeletal trauma care.Key HighlightsMAPT as a scalable, master protocol for orthopaedic intervention evaluationHierarchical, patient-centered endpoint (survival, 4-level ambulation, days alive/out of hospital), analyzed with a Bayesian-modeled, non-parametric win ratioDomain-specific adaptation thresholds based on clinical differentiationInterim analyses after 100 patients, then every 50, informing early adaptation40 sites across US, Canada, and Europe, centralized data management at McMasterA unified DSMB structure with capacity for domain-specific expertise as neededTiered protocol access: open sharing, collaboration, direct integrationInfrastructure enables rapid domain addition and multi-investigator participationFor more, visit us at https://www.berryconsultants.com/

This week on AWM Insights, Chief Investment Officer Justin Dyer and Portfolio Manager Mena Hanna break down the turbulence across markets, from precious metals and Bitcoin to tech stocks under pressure. As they unpack the sharp drawdowns and shifting narratives shaping the start of 2026, Justin and Mena draw on real stories, sports analogies, and candid opinions to highlight why fundamentals, discipline, and diversification remain the bedrock of lasting wealth. If you want to hear what separates speculation from true investing—and how the habits that build champions apply to generational wealth—this episode offers timely wisdom you won't want to miss.Chapters(00:00) Market Volatility and Mixed Signals(01:20) Precious Metals and Bitcoin Struggles(02:21) Diversification Versus Speculation(04:24) Foundational Principles of Investing(06:24) Discipline and Avoiding Behavioral Pitfalls(11:16) Long-Term Mindset and Staying the CourseConnect with Us• Call or text us: 626-862-0355• Website: https://www.athletefamilyoffice.com/• YouTube: https://www.youtube.com/channel/UCc1NxpK21N1vKWEExC45YEA• LinkedIn: https://www.linkedin.com/company/awmcapital/• Instagram: https://www.instagram.com/awmcapital/• X: https://twitter.com/awmcapital• Facebook: https://www.facebook.com/awmcapital/

SummaryIn this episode of the Breakthrough Church podcast, the host shares a recap of the recent Breakthrough Summit and All Church Retreat, emphasizing the empowerment of church members through the authority given by Jesus to heal and bless others. The conversation transitions into a personal journey of faith, highlighting the importance of belief and action in the healing process. The episode concludes with announcements of upcoming events aimed at community engagement and outreach.Chapters00:00 Welcome and Summit Recap06:11 Personal Journey of Faith and Healing

In this episode, Paul Spencer explores why conventional approaches to business efficiency and cost-cutting might be limiting your company’s long-term potential. Drawing from Deming’s principles, Paul breaks down the often-overlooked impact of prioritizing price over quality, the hidden pitfalls of relentless optimization, and the untapped value of building deep relationships with suppliers and even competitors. With practical stories and counterintuitive advice, this discussion is designed to help family business owners build genuine resilience and make wiser decisions amid complex tradeoffs. Tune in for a fresh perspective on creating sustainable success beyond just the bottom line.Connect with PaulWebsite: https://www.secondnature.solutions/Subscribe to the newsletter: https://www.secondnature.solutions/joinLinkedIn: https://www.linkedin.com/in/paul-spencer-7252118/Chapters(00:01) Rethinking Price-Based Procurement(02:25) Hidden Costs of Short-Term Savings(06:20) Building Loyalty with Key Suppliers(08:13) The Downsides of Over-Optimization(14:31) Embracing Competition as Part of the System

In this episode, join Switchfly's Ariella Barshay and Ian Andersen to explore what truly makes a customer experience unforgettable. Together, they unpack the art of 5-star moments, the role of thoughtful personalization, and the delicate balance between technology and human touch in service. With stories from the front lines of hotels and practical insights on empathy and communication, this conversation reveals how the smallest details can create lifelong loyalty. Tune in for actionable tips and fresh perspectives that every service professional can use to wow their guests.Chapters(00:02) Defining 5-Star Moments(01:03) Memorable Service Examples and ROI(03:22) Intentionality and Reading Customer Needs(06:08) Creative and Simple Experience Touchpoints(09:56) Personalization and Technology in Service(13:57) Balancing AI and Human Support(18:46) Empathy and Emotional Intelligence in Hospitality(21:38) Building Feedback Loops and Coordination(27:03) Using Customer Data and Institutional Knowledge(31:11) The Value of Grace and Humanity in ServiceConnect with SwitchflyWebsite: https://www.switchfly.com/LinkedIn: https://www.linkedin.com/company/switchfly/X: https://twitter.com/switchflyYouTube: https://www.youtube.com/@SwitchflyOfficial